Vahid Jazi
Research Details
Thesis Name
Evaluation of multi-strain probiotic product as an antibiotic growth promoter replacement in broiler chickens.Thesis Abstract
The withdrawal of antibiotic growth promoters (AGPs) from poultry production has increased the need for effective and sustainable alternatives that can maintain bird performance and gut health. This PhD project aims to evaluate and optimise a multistrain Bacillus-based probiotic product (Natupro) as a potential alternative to AGPs in broiler chickens. The study combines in vitro and in vivo approaches to assess the functional properties, efficacy, and mechanisms of action of this probiotic.
In vitro assays will characterise key probiotic traits, including antimicrobial activity against major enteric pathogens such as Salmonella, Escherichia coli, and Clostridium perfringens, as well as adhesion to intestinal epithelial cells and tolerance to acidic conditions and bile salts. In vivo trials will evaluate growth performance, gut morphology, microbial ecology, and immune responses in broilers under AGP replacement programs.
The project will also examine synergistic strategies by combining Natupro with feed additives such as acidifiers and proteases to improve nutrient utilisation, gut health, and pathogen control. Advanced approaches, including microbiome and metabolome analyses, will be used to identify functional changes and potential biomarkers associated with improved performance.
Overall, this research aims to provide both mechanistic and applied evidence supporting the use of multistrain Bacillus probiotics as effective alternatives to AGPs, with direct relevance to commercial poultry production and feed industry applications
