Breadcrumb Links:

Mechanisms Linking Sedentary Behaviour to Cardiometabolic and Cancer Risks

Author(s): Romeo Batacan Jr.
Supervisor(s): Dr. Andrew Fenning, Dr. Mitch Duncan, Dr. Vincent Dalbo

Field of Research: Medical and Health Sciences
Research Organisation: School of Medical and Applied Sciences

Abstract

Rapidly increasing evidence suggests that sedentary behaviour is associated with increase health risks. However, most of the studies in sedentary behaviour do not provide insight on the mechanisms that may be driving the adverse health outcomes associated with prolonged and uninterrupted sitting. The most direct effect of sitting elucidated so far is that sitting for prolonged periods causes suppression of skeletal muscle lipoprotein lipase activity and reduced glucose uptake contributing to metabolic dysfunction. Although this mechanism has remained to be the prevailing theory explaining the health effects of sedentary behaviour, increased adiposity, oxidative stress and inflammation are now receiving increasing attention as potential mechanisms mediating the sedentary behaviour-disease risk association. This project, therefore, aims to elucidate the putative mechanisms linking sedentary behaviour to cardiometabolic disease and cancer risks by using animal and human models.

Keywords: Sedentary behaviour, Sitting, Cardiometabolic disease, Cancer, Physical Activity, Inflammation, Adiposity, Oxidative stress
Timeline: August 2014

Project Contacts

Name: Dr. Andrew Fenning
Contact Research Organisation: School of Medical and Applied Sciences
Phone: +61 7 4923 2568
Email: a.fenning@cqu.edu.au