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The Acute and Chronic Effects of Aerobic Exercise on Markers of Oxidative Stress, Antioxidant Activity, and Inflammation in Patients with Stage 3 Chronic Kidney Disease

Author(s): Patrick Tucker, Vincent Dalbo, Michael Kingsley
Supervisor(s): Vincent Dalbo, Michael Kingsley

Field of Research: Medical and Health Sciences
Research Organisation: Institute for Health and Social Science Research

Abstract

Kidney-related pathologies have substantial impact on health, have rising prevalence rates, and produce considerable financial burden. CKD is characterized by increased levels of inflammation and reactive oxygen/nitrogen species (RONS), resulting in kidney-specific and systemic tissue damage. Chronic aerobic exercise has been shown to lower basal levels of oxidative stress and inflammation. However, little research has been conducted to describe the effects of chronic aerobic exercise on levels of oxidative stress, antioxidant activity, and inflammation in patients with CKD. This investigation will examine the effects of 12 weeks of aerobic exercise on markers of oxidative stress, antioxidant status, and inflammation in patients with Stage 3 CKD. Characterizing the effects of chronic aerobic exercise on these markers will benefit clinicians who wish to explore novel therapeutic options and researchers who wish to have a more comprehensive view of the body’s training-induced adaptations in the presence of CKD. It is hypothesized that the proposed aerobic exercise intervention will prove beneficial in this population, leading to the development of novel, low-cost, widely-available therapeutic options for patients with CKD.

Keywords: antioxidant status, reactive oxygen species, reactive nitrogen species, inflammation, renal disease, renal failure, kidney disease, chronic kidney disease
Timeline: May 2013

Project Contacts

Name: Patrick Tucker
Contact Research Organisation: Institute for Health and Social Science Research
Phone: 617 4923 2109
Email: p.tucker@cqu.edu.au